<i>In situ</i> generation and conversion of a half-zirconocene catalyst for the synthesis of <i>N</i>-acylpyrazoles.

ABSTRACT: Pyrazoles are an important class of five-membered nitrogen heterocyclic compounds that have been widely used in agriculture and medicine. Exploring their synthesis methods under mild conditions has always been a hot research topic. Herein, a new strategy was developed to enhance the activity of a zirconium metal centre for the synthesis of N-acylpyrazole derivatives using Cp₂ZrCl₂ as a pre-catalyst. Cp₂ZrCl₂ was activated in situ within the catalytic system through cyclopentadienyl ring dissociation, leading to the formation of an activated species, [CpZrCl(acac)₂]. The new approach demonstrates broad substrate scope under mild reaction conditions, leading to formation of (3,5-dimethyl-1H-pyrazol-1-yl)(phenyl)metha

SUBMITTER: Wu J 

PROVIDER: S-EPMC11744458 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature