Corneal Mucin-Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation.

ABSTRACT: The incidence of dry eye disease (DED) has been increasing annually worldwide, creating an urgent need for new therapies. Due to the multifactorial mechanism underlying DED, traditional medications focused on decreasing ocular surface inflammation have been unable to address all the harmful factors and fail to achieve a complete clinical cure. Ferroptosis, a new form of programmed cell death characterized by lipid peroxidation, has become a pivotal contributor to dry eye oxidative stress-driven pathology. Therefore, therapeutic targeting of ferroptosis may be an attractive option for dry eye management. Herein, a sialic acid-targeting peptide-modified liposome loaded with Cyclosporine A (CsA), a typical anti-inflammatory drug, and Ferrostatin-1 (Fer-1), a selective ferroptosis inhibitor, i

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11744570 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature