Development of a Novel Rat Knee Osteoarthritis Model Induced by Medial Meniscus Extrusion.

ABSTRACT:

Objective

The medial meniscus extrusion (MME) is associated with increased stress on the knee joint, which leads to cartilage degeneration. To evaluate the etiology of knee osteoarthritis, it is extremely important to create animal models of the disease that more closely resemble actual clinical conditions in terms of symptomatology, molecular biology, and histology. This study aimed to create a clinically relevant model of MME in rats.

Design

Behavioral, molecular biological, and histological changes in the newly developed rat MME model were compared with those in sham and medial meniscus transection and medial collateral ligament transection (MMT) models to examine the characteristics of this model.

Results

In the MME rat model, behavioral evaluation shows abnormali

SUBMITTER: Fukui D 

PROVIDER: S-EPMC11744626 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature