Modulation of the mechanism of action of antibacterial silver N-heterocyclic carbene complexes by variation of the halide ligand.

ABSTRACT: The antimicrobial properties of silver and silver complexes have been known in medicine since ancient times. However, limitations in stability and solubility have impaired medicinal chemistry and drug development research. With the advent of N-heterocyclic carbenes (NHC) as ligands, the development of synthesis methods for organometallic silver species of the type (NHC)AgX (where X = halide) has brought significant improvements, and the class of antimicrobial silver NHC complexes has emerged. However, reports studying structure-activity relationships and the mechanism of action of this compound type are still rare. This paper explores the activity of silver NHC complexes with halide (chloride, iodide) ligands and attempts to elucidate their mechanism of antibacterial action in Gram-negativ

SUBMITTER: Esarev IV 

PROVIDER: S-EPMC11744769 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature