Characterization of Amorphous Ibrutinib Thermal Stability.

ABSTRACT: The choice of method for drug amorphization depends on various factors, including the physicochemical properties of the active pharmaceutical ingredients, the desired formulation, and scalability requirements. It is often important to consider a combination of methods or the use of excipients to further enhance the stability and performance of the amorphous drug. This study presents a comparison of techniques including melt quench, hot melt extrusion, solvent evaporation, ball milling, and lyophilization used for the preparation of amorphous ibrutinib. The amorphous material was thoroughly investigated using numerous techniques to examine changes in the physicochemical properties, stability, and degradation pathways of the drug product. During the examination, the temperature was discovere

SUBMITTER: Trunov D 

PROVIDER: S-EPMC11744788 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature