Dual role of Cathepsin S in cutaneous melanoma: insights from mendelian randomization and bioinformatics analysis.

ABSTRACT:

Background

Cutaneous melanoma (CM) is strongly associated with ultraviolet (UV) radiation, which contributes to the transformation of melanocytes into melanoma by inducing specific DNA damage. Here, we investigated the causal relationship between CM and genes related to sun-damaged skin, exploring specific target genes through various bioinformatics analyses.

Methods

The Gene Expression Omnibus (GEO) database was used to obtain differential genes for CM and normal skin, and the Genome-Wide Association Studies (GWAS) analysis offered summary-level melanoma data for CM. Mendelian randomization (MR) analyses were used to examine the correlated linkage between CM and sun-exposed skin genes. The MR studies were conducted mainly using Inverse Variance Weighting (IVW), MR-Egger, We

SUBMITTER: Zhou L 

PROVIDER: S-EPMC11744831 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature