Targeting enolase 1 reverses bortezomib resistance in multiple myeloma through YWHAZ/Parkin axis.

ABSTRACT:

Background

Enolase 1 (ENO1) is a conserved glycolytic enzyme that regulates glycolysis metabolism. However, its role beyond glycolysis in the pathophysiology of multiple myeloma (MM) remains largely elusive. Herein, this study aimed to elucidate the function of ENO1 in MM, particularly its impact on mitophagy under bortezomib-induced apoptosis.

Methods

The bone marrow of clinical MM patients and healthy normal donors was used to compare the expression level of ENO1. Using online databases, we conducted an analysis to examine the correlation between ENO1 expression and both clinicopathological characteristics and patient outcomes. To investigate the biological functions of ENO1 in MM and the underlying molecular mechanisms involved, we conducted the following experiment: cons

SUBMITTER: Gao X 

PROVIDER: S-EPMC11744840 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature