Causal association between circulating α-Klotho levels and venous thromboembolism: a two-sample Mendelian randomization study.

ABSTRACT:

Background

α-Klotho may involve in the occurrence and development of venous thromboembolism (VTE). However, the underlying relationship between circulating α-Klotho levels and VTE is still unclear.

Methods

This two-sample Mendelian Randomization (MR) study aims to explore the causal associations of circulating α-Klotho levels with different types of venous thromboembolism. Data of exposure and outcomes were extracted from the genome-wide association study (GWAS) of the MRC Integrative Epidemiology Unit (MRC-IEU). The fixed inverse variance weighted (IVW), MR-Egger, MR-Robust Adjusted Profile Score (RAPS) and the weighted-median methods were utilized to investigate the causal associations of circulating α-Klotho levels with different types of VTE. The effect size was expresse

SUBMITTER: Song Y 

PROVIDER: S-EPMC11744900 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature