Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex.

ABSTRACT: Communication sound processing in mouse AC is lateralized. Both left and right AC are highly specialised and differ in auditory stimulus representation, functional connectivity and field topography. Previous studies have highlighted intracortical functional circuits that explain hemispheric stimulus preference. However, the underlying microstructure remains poorly understood. In this study, we examine structural lateralization of AC on the basis of immunohistochemically stained and tissue-cleared adult mouse brains (n = 11). We found hemispheric asymmetries of intracortical myelination, most prominently in layer 2/3, which featured more intercolumnar connections in the right AC. Furthermore, we found a larger structural asymmetry in the right AC. We also investigated sex differences. In ma

SUBMITTER: Ruthig P 

PROVIDER: S-EPMC11744913 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature