Clinical measures in chronic neuropathic pain are related to the Kennedy and endocannabinoid pathways.

ABSTRACT:

Background

Chronic neuropathic pain (CNP) is a debilitating condition, often refractory to currently available drugs. Understanding biochemical alterations in peripheral tissues such as blood will be useful for understanding underlying pathophysiological processes relating to CNP.

Methods

We collected blood from two independent cohorts of CNP and pain-free controls (CNP n = 129/Controls n = 127) in the UK and Ireland to investigate the relationship between CNP-associated molecular/biochemical alterations and a range of clinical and pain metric parameters. Multiple statistical comparisons were conducted on the data, with selected variables included in one or more of the intended inferential analyses (six models).

Results

Gene expression analysis showed that choline pho

SUBMITTER: Bourke SL 

PROVIDER: S-EPMC11744925 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature