Urinary phthalate metabolites associated with increased prevalence of gallstone disease in U.S. adults: data from the NHANES study.

ABSTRACT:

Background

Phthalate exposure has been hypothesized to influence cholesterol metabolism and gallstone pathogenesis, but previous studies are limited. We aimed to examine the associations between urinary phthalate metabolites and prevalence of gallstone disease in a nationally representative sample.

Methods

We analyzed data on 1,696 adults aged ≥ 30 years from the National Health and Nutrition Examination Survey (NHANES) 2017-2018. Gallstone disease was defined based on self-reported physician-diagnosis. Exposure was measured by urinary concentrations of 10 phthalate metabolites. Multivariable logistic regression model was to assess individual exposure-effect associations. Weighted quantile sum (WQS) regression, Quantile g-computation (Qgcomp) analysis and Bayesian kernel mac

SUBMITTER: Jia F 

PROVIDER: S-EPMC11744960 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature