Fecal occult blood affects intestinal microbial community structure in colorectal cancer.

ABSTRACT:

Background

Gut microbes have been used to predict CRC risk. Fecal occult blood test (FOBT) has been recommended for population screening of CRC.

Objective

To analyze the effects of fecal occult blood test (FOBT) on gut microbes.

Methods

Fecal samples from 107 healthy individuals (FOBT-negative) and 111 CRC patients (39 FOBT-negative and 72 FOBT-positive) were included for 16 S ribosomal RNA sequencing. Based on the results of different FOBT, the community structure and diversity of intestinal bacteria in healthy individuals and CRC patients were analyzed. Characteristic gut bacteria were screened, and various machine learning algorithms were applied to construct CRC risk prediction models.

Results

The gut microbiota of healthy people and CRC patients with diffe

SUBMITTER: Guodong W 

PROVIDER: S-EPMC11745023 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature