The interplay between RNA m6A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review.

ABSTRACT: The diverse radiation types in medical treatments and the natural environment elicit complex biological effects on both cancerous and non-cancerous tissues. Radiation therapy (RT) induces oncological responses, from molecular to phenotypic alterations, while simultaneously exerting toxic effects on healthy tissue. N⁶-methyladenosine (m⁶A), a prevalent modification on coding and non-coding RNAs, is a key epigenetic mark established by a set of evolutionarily conserved enzymes. The interplay between m⁶A modification and radiobiology of cancerous and non-cancerous tissues merits in-depth investigation. This review summarizes the roles of m⁶A in the biological effects induced by ionizing radiation and ultraviolet (UV) radiation. It begins with an ove

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC11745087 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature