Cortical Gyrification and Cognitive Decline in the Human Brain With Type 2 Diabetes Mellitus.

ABSTRACT:

Introduction

Type 2 diabetes mellitus (T2DM) is linked to abnormal brain structure and cognitive dysfunction. However, there is a lack of studies conducted to assess the impact of diabetes on cortical gyrification and cognition. The aim of this cross-sectional study was to assess the potential negative effects of glucose metabolism levels on cognition and cortical gyrification in T2DM.

Methods

The current study comprised 83 patients with T2DM and 60 individuals with normal glucose metabolism (NGM). The calculation of the local gyrification index (LGI) was performed utilizing the FreeSurfer software. Subsequently, between-group differences were examined through the utilization of analysis of covariance. Multivariable linear regression and mediation models were employed to inv

SUBMITTER: Lu W 

PROVIDER: S-EPMC11745154 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature