Individualized temporal patterns drive human sleep spindle timing.

ABSTRACT: Sleep spindles are cortical electrical oscillations considered critical for memory consolidation and sleep stability. The timing and pattern of sleep spindles are likely to be important in driving synaptic plasticity during sleep as well as preventing disruption of sleep by sensory and internal stimuli. However, the relative importance of factors such as sleep depth, cortical up/down-state, and temporal clustering in governing sleep spindle dynamics remains poorly understood. Here, we analyze sleep data from 1,025 participants, statistically modeling the simultaneous influences of multiple factors on moment-to-moment spindle production using a point process-generalized linear model framework. Results reveal fingerprint-like timing patterns, characterized by a refractory period followed by

SUBMITTER: Chen S 

PROVIDER: S-EPMC11745340 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature