A synapse-specific refractory period for plasticity at individual dendritic spines.

ABSTRACT: How newly formed memories are preserved while brain plasticity is ongoing has been a source of debate. One idea is that synapses which experienced recent plasticity become resistant to further plasticity, a type of metaplasticity often referred to as saturation. Here, we probe the local dendritic mechanisms that limit plasticity at recently potentiated synapses. We show that recently potentiated individual synapses exhibit a synapse-specific refractory period for further potentiation. We further found that the refractory period is associated with reduced postsynaptic CaMKII signaling; however, stronger synaptic activation fully restored CaMKII signaling but only partially restored the ability for further plasticity. Importantly, the refractory period is released after one hour, a timing th

SUBMITTER: Flores JC 

PROVIDER: S-EPMC11745398 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature