Choroid Plexus Volume, Amyloid Burden, and Cognition in the Alzheimer's Disease Continuum.

ABSTRACT: As a part of the glymphatic system, the choroid plexus (CP) is involved in the clearance of harmful metabolites from the brain. We investigated the association between CP volume (CPV), amyloid-β (Aβ) burden, and cognition in patients on the Alzheimer's disease (AD) continuum. We retrospectively reviewed the records of 203 patients on the AD continuum and 82 healthy controls who underwent brain magnetic resonance imaging and ¹⁸F-florbetaben positron emission tomography. Automatic segmentation was performed, and the CPV was calculated. Cognitive function was assessed using detailed neuropsychological tests, and patients on the AD continuum were categorized into the non-dementia and dementia groups. The relationships between CPV, Aβ burden, and cognitive function were assessed usin

SUBMITTER: Jeong SH 

PROVIDER: S-EPMC11745423 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature