Elevated CD4⁺ T Cell Senescence Associates with Impaired Immune Responsiveness in Severe COVID-19.

ABSTRACT: Aging is a critical risk factor for unfavorable clinical outcomes among COVID-19 patients and may impact vaccine efficacy. However, whether the senescence of T cells is associated with severe COVID-19 outcome in elderly individuals is unclear. Using flow cytometry, we analyzed the frequency of senescent T cells (Tsens) in peripheral blood from 100 hospitalized elderly COVID-19 patients and compared differences between those with mild/moderate and severe/critical illness. We also assessed correlations between the percentage of Tsens and the quantity and quality of spike-specific antibodies by ELISA, neutralizing antibody test kit, and ELISPOT assay respectively, the cytokine production profile of COVID-19 reactive T cells, and plasma soluble factors by cytometric bead array (CBA). Our study

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11745426 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature