Convergence of Accelerated Brain Volume Decline in Normal Aging and Alzheimer's Disease Pathology.

ABSTRACT:

Background

Age represents the largest risk factor for Alzheimer's disease (AD) but is typically treated as a covariate. Still, there are similarities between brain regions affected in AD and those showing accelerated decline in normal aging, suggesting that the distinction between the two might fall on a spectrum.

Objective

Our goal was to identify regions showing accelerated atrophy across the brain and investigate whether these overlapped with regions involved in AD or where related to amyloid.

Methods

We used a longitudinal sample of 137 healthy older adults from the Alzheimer's Disease Neuroimaging Initiative (ADNI), who underwent magnetic resonance imaging (MRI). In addition, a total of 79 participants also had longitudinal positron emission tomography (PET) data

SUBMITTER: Avelar-Pereira B 

PROVIDER: S-EPMC11745547 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature