Imperatorin's Effect on Myocardial Infarction Based on Network Pharmacology and Molecular Docking.

ABSTRACT: Purpose: Myocardial infarction (MI), a severe cardiovascular disease, is the result of insufficient blood supply to the myocardium. Despite the improvements of conventional therapies, new approaches are needed to improve the outcome post-MI. Imperatorin is a natural compound with multiple pharmacological properties and potential cardioprotective effects. Therefore, this work investigated imperatorin's therapeutic effects and its mechanism of action in an MI mouse model. Methods: Network pharmacology, molecular docking, and experimental validation were performed for exploring the pharmacokinetic properties, therapeutic effects, and molecular targets of imperatorin in MI. Permanent ligation of the left anterior descending artery was performed in male C57BL/6 mice to induce MI b

SUBMITTER: Zhang R 

PROVIDER: S-EPMC11745561 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature