Intraoperative goal-directed fluid management and postoperative brain edema in patients having high-grade gliomas resections: a randomized trial.

ABSTRACT:

Introduction

Patients with high-grade gliomas often have severe brain edema. Goal-directed fluid management protects neurological function, but whether reduces postoperative brain edema remains unknown.

Methods

Patients having elective resection of supratentorial malignant gliomas were randomly assigned to goal-directed versus routine fluid management. Patients assigned to goal-directed management group were given 3 ml kg -1 hydroxyethyl starch solution when stroke volume variation exceeded 15% for 5 min. Fluid was managed per routine by attending anesthesiologists in reference patients. The primary outcome was cerebral edema volume after surgery as assessed by computerized tomography.

Results

A total of 480 eligible patients were randomly assigned to the goal-directe

SUBMITTER: Liu X 

PROVIDER: S-EPMC11745616 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature