Exploring potential plasma drug targets for cholelithiasis through multiancestry Mendelian randomization.

ABSTRACT:

Background

Cholelithiasis poses significant health and economic burdens, necessitating novel pharmacological targets to enhance treatment efficacy.

Method

Based on genome-wide association analysis studies, the authors performed a two-sample Mendelian randomization (MR) analysis based on plasma proteomics to explore potential drug targets in European (n Case =40 191 and n Control =361 641) and Asian (n Case =9305 and n Control =168 253) populations. The authors confirmed the directionality and robust correlation of the drug targets with the results through reverse MR analysis, Steiger filtering, Bayesian colocalization, phenotype scanning, and replication in multiple databases. Further exploration of the safety and possible mechanisms of action of phenome-wide MR analysis and

SUBMITTER: Liu X 

PROVIDER: S-EPMC11745627 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature