Development of a staging system for hepatoid adenocarcinoma of the stomach based on multicenter data: a retrospective cohort study.

ABSTRACT:

Background

Hepatoid adenocarcinoma of the stomach (HAS) is a rare subtype of gastric cancer (GC) with a poor prognosis. Furthermore, the current pathological staging system for HAS does not distinguish it from that for common gastric cancer (CGC).

Methods

The clinicopathological data of 251 patients with primary HAS who underwent radical surgery at 14 centers in China from April 2004 to December 2019 and 5082 patients with primary CGC who underwent radical surgery at two centers during the same period were retrospectively analyzed. A modified staging system was established based on the differences in survival.

Results

After 1:4 propensity score matching (PSM), 228 patients with HAS and 828 patients with CGC were analyzed. Kaplan-Meier (K-M) analysis showed patients wi

SUBMITTER: Huang YQ 

PROVIDER: S-EPMC11745678 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature