Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845 492 individuals: a diagnostic study.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) significantly impacts individuals due to its prevalence and negative effect on quality of life. Current genome-wide association studies (GWAS) have only identified a small number of crucial single nucleotide polymorphisms (SNPs), not fully elucidating IBS's pathogenesis.

Objective

To identify genomic loci at which common genetic variation influences IBS susceptibility.

Methods

Combining independent cohorts that in total comprise 65 840 cases of IBS and 788 652 controls, the authors performed a meta-analysis of genome-wide association studies (GWAS) of IBS. The authors also carried out gene mapping and pathway enrichment to gain insights into the underlying genes and pathways through which the associated loci contribute to dise

SUBMITTER: Huang W 

PROVIDER: S-EPMC11745715 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature