Effect of carbon nanoparticle suspension injection versus indocyanine green tracer in guiding lymph node dissection during radical gastrectomy (FUTURE-01): a randomized clinical trial.

ABSTRACT:

Background

Carbon nanoparticle suspension injection (CNSI) and indocyanine green (ICG) have both been applied intraoperatively to facilitate lymphatic mapping and postoperatively to sort lymph nodes (LNs) in gastric cancer patients. However, no study has compared the two tracers in gastric cancer patients.

Materials and methods

This prospective randomized controlled trial was conducted from January 2022 to March 2023. Patients with potentially resectable gastric cancer (cT1-4a N0/+ M0) were randomized to the CNSI or ICG group.

Results

This study enrolled 96 patients. Ninety patients were in the modified intention-to-treat population, including 46 patients [32 males and 14 females; mean (SD) age, 57.4 (9.4) years] in the CNSI group and 44 patients [31 males and 13 fema

SUBMITTER: Tian Y 

PROVIDER: S-EPMC11745718 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature