Comparison of the Abbott Alinity m and Qiagen Artus assays for the quantification of BK virus in clinical samples.

ABSTRACT:

Objectives

BK virus (BKV) is highly seroprevalent in humans. After primary infection, it remains latent in the urinary tract and can reactivate in immunocompromised individuals, leading to interstitial nephropathy or hemorrhagic cystitis. The BKV viral load (VL) in plasma correlates with the occurrence of nephropathy and can be monitored in kidney graft recipients; the early detection of BKV viremia can enable an early reduction of immunosuppressant drug doses and the prevention of BKV-associated nephropathy. BKV VL is measured using real-time reverse transcription-polymerase chain reaction. Our aim was to evaluate the Abbott Alinity m BKV AMPL kit versus the Artus BKV quantification kit (Qiagen, Hilden, Germany).

Methods

We compared the methods on 69 plasma samples, 54 urin

SUBMITTER: Fenaux H 

PROVIDER: S-EPMC11745809 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature