NTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas.

ABSTRACT: The neurotrophic tyrosine kinase receptor (NTRK) gene family is of rising importance as their fusions are oncogenic, and specific target drugs are available to inhibit the chimera proteins. Pan-TRK antibody, which shows the overexpression of the NTRK1-2-3 genes, is a useful tool to detect tumors with or without NTRK gene alterations, due to high negative predictive value. Though it is well known that pan-TRK immunopositivity is usually not connected to NTRK fusion, the role of other possible genetic alterations is under-researched. In our previous work, we found 3 NTRK1 amplified cases out of 6 cases with recurrent NTRK1 tyrosine kinase domain mutation pair, so we extended our investigation to a larger series to estimate amplification freque

SUBMITTER: Lippai Z 

PROVIDER: S-EPMC11745873 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature