Guizhi Fuling Wan ameliorates concanavalin A-induced autoimmune hepatitis in mice.

ABSTRACT:

Background

Autoimmune hepatitis (AIH) is an immune-mediated hepatic disease associated with intense complications. AIH is more common in females and needs effective drugs to treat. Guizhi Fuling Wan (GZFLW) is a traditional Chinese herbal formula for treating various gynecologic diseases. In this study, we aim to extend the new use of GZFLW for AIH.

Methods

The tandem MS-based analysis was used to identify secondary metabolites in GZFLW. Therapeutic effects of GZFLW were tested in a concanavalin A (Con A)-induced AIH model in mice. Ethnopharmacological mechanisms underlying the antiapoptotic, antioxidant, and immunomodulatory protective effects were determined.

Results

Oral administration of GZFLW attenuates AIH in a Con A-induced hepatotoxic model in vivo. The tandem

SUBMITTER: Kuo SL 

PROVIDER: S-EPMC11745949 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature