Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery.

ABSTRACT: Opioids have been the primary method used to manage pain for hundreds of years, however the increasing prescription rate of these drugs in the modern world has led to a public health crisis of overdose related deaths. Naloxone is the current standard treatment for opioid overdose rescue, but it has not been fully investigated for potential off-target toxicity effects. The current methods for pharmaceutical development do not correlate well with pre-clinical animal studies compared to clinical results, creating a need for improved methods for therapeutic evaluation. Microphysiological systems (MPS) are a rapidly growing field, and the FDA has accepted this area of research to address this concern, offering a promising alternative to traditional animal models. This study establishes a novel

SUBMITTER: Patel A 

PROVIDER: S-EPMC11745978 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature