Restoring natural killer cell activity in lung injury with 1,25-hydroxy vitamin D₃: a promising therapeutic approach.

ABSTRACT:

Background and aim

NK cells and NK-cell-derived cytokines were shown to regulate neutrophil activation in acute lung injury (ALI). However, the extent to which ALI regulates lung tissue-resident NK (trNK) activity and their molecular phenotypic alterations are not well defined. We aimed to assess the impact of 1,25-hydroxy-vitamin-D3 [1,125(OH)₂D] on ALI clinical outcome in a mouse model and effects on lung trNK cell activations.

Methods

Oleic acid (OA)-induced ALI in C57BL/6J mice and 1,25(OH)₂D treatment 2×/2 weeks were performed. Lung tissue was harvested to assess alveolar I/II cell apoptosis and lung injury marker of Surfactant-Protein-D (SP-D). Pulmonary edema markers of epithelial sodium channel, cystic fibrosis transmembrane conductance regulato

SUBMITTER: Amer J 

PROVIDER: S-EPMC11746039 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature