Serum proteomic and metabolomic profiling of hepatocellular carcinoma patients co-infected with <i>Clonorchis sinensis</i>.

ABSTRACT:

Background

Clonorchis sinensis (C. sinensis) infection is a significant risk factor for hepatocellular carcinoma (HCC), yet its underlying mechanisms remain poorly understood. This study aimed to investigate the impact of C. sinensis infection on the serum proteomic and metabolomic profiling of HCC patients, focusing on the potential mechanisms.

Method

A retrospective clinical analysis was conducted on 1121 HCC patients, comparing those with and without C. sinensis infection. The influence of C. sinensis on serum proteome and metabolome in HCC was further assessed.

Result

C. sinensis infection correlated with a younger age at cancer onset, male predominance, advanced cancer stage, liver cirrhosis, and microvascular invasion in

SUBMITTER: Tang Z 

PROVIDER: S-EPMC11746118 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature