Apigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages independently of CD38.

ABSTRACT:

Introduction

CD38, a regulator of intracellular calcium signalling, is highly expressed in immune cells. Mice lacking CD38 are very susceptible to acute bacterial infections, implicating CD38 in innate immune responses. The effects of CD38 inhibition on NLRP3 inflammasome activation in human primary monocytes and monocyte-derived macrophages have not been investigated. Apigenin is a naturally occurring flavonoid known to inhibit CD38. However, apigenin has also been proposed to inhibit the extracellular ATP receptor P2XR7, an upstream activator of NLRP3. In this study we aimed to investigate whether apigenin attenuates NLRP3 inflammasome activation in human monocytes and monocyte-derived macrophages through CD38 inhibition.

Methods

LPS-primed human monocytes and monocyte-der

SUBMITTER: Lauritzen KH 

PROVIDER: S-EPMC11746122 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature