Child maltreatment as a transdiagnostic risk factor for the externalizing dimension: a Mendelian randomization study.

ABSTRACT: Observational studies suggest that child maltreatment increases the risk of externalizing spectrum disorders such as attention deficit hyperactivity disorder (ADHD), conduct disorder (CD), antisocial personality disorder (ASPD), and substance use disorder (SUD). Yet, only few of such associations have been investigated by approaches that provide strong evidence for causation, such as Mendelian Randomization (MR). Establishing causal inference is essential given the growing recognition of gene-environment correlations, which can confound observational research in the context of childhood maltreatment. Evaluating causality between child maltreatment and the externalizing phenotypes, we used genome-wide association study (GWAS) summary data for child maltreatment (143,473 participants), ADHD

SUBMITTER: Konzok J 

PROVIDER: S-EPMC11746131 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature