Convergent functional effects of antidepressants in major depressive disorder: a neuroimaging meta-analysis.

ABSTRACT:

Background

Neuroimaging studies have provided valuable insights into the macroscale impacts of antidepressants on brain functions in patients with major depressive disorder. However, the findings of individual studies are inconsistent. Here, we aimed to provide a quantitative synthesis of the literature to identify convergence of the reported findings at both regional and network levels and to examine their associations with neurotransmitter systems.

Methods

Through a comprehensive search in PubMed and Scopus databases, we reviewed 5258 abstracts and identified 36 eligible functional neuroimaging studies on antidepressant effects in major depressive disorder. Activation likelihood estimation was used to investigate regional convergence of the reported foci of antidepressant

SUBMITTER: Saberi A 

PROVIDER: S-EPMC11746144 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature