Airborne Escherichia coli bacteria biosynthesize lipids in response to aerosolization stress.

ABSTRACT: Gram-negative bacteria pose an increased threat to public health because of their ability to evade the effects of many antimicrobials with growing antibiotic resistance globally. One key component of gram-negative bacteria resistance is the functionality and the cells' ability to repair the outer membrane (OM) which acts as a barrier for the cell to the external environment. The biosynthesis of lipids, particularly lipopolysaccharides, or lipooligosaccharides (LPS/LOS) is essential for OM repair. Here we show the phenotypic and genotypic changes of Escherichia coli MG1655 (E. coli) before and after exposure to short-term aerosolization, 5 min, and long-term indoor aerosolization, 30 min. Short-term aerosolization samples exhibited major damages to the OM and resulted in the elongation of t

SUBMITTER: Smith BL 

PROVIDER: S-EPMC11746921 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature