Metabolic activities are selective modulators for individual segmentation clock processes.

ABSTRACT: Numerous cellular and molecular processes during embryonic development prompt the fundamental question of how their tempos are coordinated and whether a common global modulator exists. While the segmentation clock tempo scales with the kinetics of gene expression and degradation processes of the core clock gene Hes7 across mammals, the coordination of these processes remains unclear. This study examines whether metabolic activities serve as a global modulator for the segmentation clock, finding them to be selective instead. Several metabolic inhibitions extend the clock period but affect key processes differently: glycolysis inhibition slows Hes7 protein degradation and production delay without altering intron delay, while electron transport chain inhibition extends intron delay without in

SUBMITTER: Matsuda M 

PROVIDER: S-EPMC11746943 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature