Single-cell landscape of the intrahepatic ecosystem in alcohol-related liver disease.

ABSTRACT: Alcohol-related liver disease (ALD) is a common chronic liver disease caused by long-term excessive alcohol consumption and responsible for more than half of all liver-related deaths worldwide. The molecular mechanisms associated with ALD were not fully understood. In this study, we performed single-cell RNA sequencing on liver tissues obtained from ALD patients and healthy liver donors. We identified an ALB⁺KRT7⁺ epithelial population that expressed both hepatocyte and biliary markers significantly expanded in ALD livers. The ALB⁺KRT7⁺ epithelial cells were demonstrated to have stem cell properties and malignant transformation potentials. Moreover, ALB⁺KRT7⁺ epithelium-derived ALD organoids promote the tumour growth by acti

SUBMITTER: Zhao X 

PROVIDER: S-EPMC11746962 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature