Optimized breath analysis: customized analytical methods and enhanced workflow for broader detection of VOCs.

ABSTRACT:

Introduction

Breath Volatile organic compounds (VOCs) are promising biomarkers for clinical purposes due to their unique properties. Translation of VOC biomarkers into the clinic depends on identification and validation: a challenge requiring collaboration, well-established protocols, and cross-comparison of data. Previously, we developed a breath collection and analysis method, resulting in 148 breath-borne VOCs identified.

Objectives

To develop a complementary analytical method for the detection and identification of additional VOCs from breath. To develop and implement upgrades to the methodology for identifying features determined to be "on-breath" by comparing breath samples against paired background samples applying three metrics: standard deviation, paired t-test, and

SUBMITTER: Arulvasan W 

PROVIDER: S-EPMC11747010 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature