Effects of psychedelics on opioid use disorder: a scoping review of preclinical studies.

ABSTRACT: The current opioid crisis has had an unprecedented public health impact. Approved medications for opioid use disorder (OUD) exist, yet their limitations indicate a need for innovative treatments. Limited preliminary clinical studies suggest specific psychedelics might aid OUD treatment, though most clinical evidence remains observational, with few controlled trials. This review aims to bridge the gap between preclinical findings and potential clinical applications, following PRISMA-ScR guidelines. Searches included MEDLINE, Embase, Scopus, and Web of Science, focusing on preclinical in vivo studies involving opioids and psychedelics in animals, excluding pain studies and those lacking control groups. Forty studies met criteria, covering both classic and non-classic psychedelics. Most studi

SUBMITTER: Pulido-Saavedra A 

PROVIDER: S-EPMC11747050 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature