Proteomic analysis identifies novel biological pathways that may link dietary quality to type 2 diabetes risk: evidence from African American and Asian cohorts.

ABSTRACT:

Background

Diet affects the development of chronic diseases such as type 2 diabetes, but the underlying biological mechanisms are only partly understood.

Objectives

This study aimed to identify proteomic markers of the Alternative Healthy Eating Index (AHEI) and the Dietary Approaches to Stop Hypertension (DASH) diet and their association with type 2 diabetes risk.

Methods

We examined the associations between the AHEI and DASH diet quality scores and 1317 plasma proteins in African American participants of the Jackson Heart Study (JHS, n = 1878). These findings were validated in a Singapore Multi-Ethnic Cohort (n = 2395) and examined in relation to type 2 diabetes incidence (n = 539 cases). We adjusted for multiple testing by using false discovery rate-adjusted q valu

SUBMITTER: Lim CG 

PROVIDER: S-EPMC11747191 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature