Evaluating the impact of donor eGFR and HLA-DR mismatch on graft survival in living donor kidney transplants.

ABSTRACT:

Background

This study assesses the impact of human leukocyte antigen (HLA)-DR mismatch and donor-estimated glomerular filtration rate (eGFR) on outcomes of living donor kidney transplantation (LDKT), which are especially relevant to the availability of multiple donors and paired kidney exchanges.

Methods

Using data from the Scientific Registry of Transplant Recipients (SRTR), we retrospectively analyzed graft survival in adult LDKT recipients transplanted between January 2013 and September 2022. Recipients with 0 HLA-DR mismatches were compared to those with 1-2 HLA-DR mismatches. Cox models assessed the association between donor eGFR and graft and patient survival, stratifying by a) HLA-DR mismatches, and b) HLA-DR mismatches and recipient age.

Results

Among 44,080 r

SUBMITTER: Budhiraja P 

PROVIDER: S-EPMC11747204 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature