Real-time trajectory imaging of alpha particles emitted from actinium-225 and its daughter radionuclides.

ABSTRACT: In targeted alpha-particle therapy, actinium-225 (Ac-225) has emerged as a radionuclide of potential, driving extensive efforts to develop innovative radiopharmaceuticals. High-resolution imaging of alpha particles is required for precisely detecting alpha-emitting radionuclides in cellular environments and small organs. Here, we report real-time trajectory imaging of alpha particles emitted by Ac-225 and its daughter radionuclides, utilizing an alpha particle trajectory imaging system. This system incorporates a magnification unit, a cooled electron-multiplying charge-coupled device (EM-CCD) camera, and a Ce-doped Gd₃Al₂Ga₃O₁₂ (GAGG) scintillator. Alpha particles were projected onto the GAGG scintillator, producing magnified images that were cap

SUBMITTER: Yamamoto S 

PROVIDER: S-EPMC11747257 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature