Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from <i>Prunella vulgaris</i> L.-<i>Taraxacum mongolicum</i> Hand.-Mazz. herb pair.

ABSTRACT:

Introduction

The Prunella vulgaris L. (PVL) and Taraxacum mongolicum Hand.-Mazz. (TH) herb pair, which is commonly used in traditional Chinese medicine (TCM), has been applied for the treatment of breast cancer. Although its efficacy is validated, the synergistic anti-breast cancer compound combinations within this herb pair and their underlying mechanisms of action remain unclear.

Methods

This study aimed to identify and validate synergistic anti-breast cancer compound combinations within the PVL-TH pair using large-scale biomedical data, artificial intelligence and experimental methods. The first step was to investigate the anti-breast cancer effects of various PVL and TH extracts using in vitro cellular assays to identify the most effective superior e

SUBMITTER: Feng C 

PROVIDER: S-EPMC11747269 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature