Investigating the preventive effects of pulsed electromagnetic fields on glucocorticoid-induced osteoporosis in rats.

ABSTRACT: The use of pulsed electromagnetic field (PEMF) has demonstrated effectiveness in the management of femoral head osteonecrosis as well as nonunion fractures; however, the effects of PEMF on preventing glucocorticoid-induced osteoporosis (GIOP) have not been extensively studied. The aim of this investigation was to explore the effectiveness of PEMF stimulation in averting GIOP in rats and uncover the potential fundamental mechanisms involved. A total of seventy-two adult male Wistar rats composed the experimental group and were subsequently assigned to three groups for treatment. (1) On the first day (day 0), 24 rats in the PEMF group were intravenously injected with lipopolysaccharide (LPS) at a concentration of 10 μg/kg. This was followed by intramuscular injections of methylprednisolone a

SUBMITTER: Ding S 

PROVIDER: S-EPMC11747287 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature