Normal weight obesity, circulating biomarkers and risk of breast cancer: a prospective cohort study and meta-analysis.

ABSTRACT:

Background

Individuals with normal weight obesity (NWO) often escape the attention of healthcare providers who may assume that a normal body mass index (BMI) correlates with low health risks. However, it remains unknown whether NWO increases the risk of breast cancer.

Methods

This study included 22,257 and 52,506 pre- and postmenopausal females with normal BMI in the UK Biobank. NWO was defined as participants with a normal BMI (18.5-24.9 kg/m2) and an excess percent body fat (PBF > 33.3%). Cox proportional hazard models were used to investigate the associations of NWO and NWO-related biomarkers with incident breast cancer.

Results

NWO was not associated with premenopausal breast cancer, whereas it was associated with a higher risk of postmenopausal breast cancer (haz

SUBMITTER: Wang W 

PROVIDER: S-EPMC11747320 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature