Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders.

ABSTRACT:

Background

Psychotic disorders are characterized by white matter (WM) abnormalities; however, their relationship with the various aspects of illness presentation remains unclear. Sleep disturbances are common in psychosis, and emerging evidence suggests that sleep plays a critical role in WM physiology. Therefore, it is plausible that sleep disturbances are associated with impaired WM integrity in these disorders. To test this hypothesis, we examined the association of self-reported sleep disturbances with WM transverse (T2) relaxation times in a cross-diagnostic sample of patients with psychosis.

Methods

A total of 28 patients with psychosis (11 schizophrenia spectrum disorders and 17 bipolar disorder with psychotic features) were included. Metabolite (N-acetyl aspartate, c

SUBMITTER: Yesilkaya UH 

PROVIDER: S-EPMC11747379 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature