Relationship between growth differentiation factor 15 and functional prognosis and severity in traumatic brain injury.

ABSTRACT: Circulating growth differentiation factor 15 (GDF-15) increases in response to inflammation and tissue damage. Its association with functional prognosis in cerebral infarction and subarachnoid hemorrhage is established; however, its role in traumatic brain injury (TBI) and its relationship with Sequential Organ Failure Assessment (SOFA) score, an indicator of systemic organ damage in TBI, remains unclear. This study aimed to explore the correlation between GDF-15 and functional outcomes at discharge in patients with TBI and stroke, including its association with SOFA scores in TBI. Patients with cerebral infarction, subarachnoid hemorrhage, and TBI transported within 24 h from July 2020 to August 2022 were included. Multivariable logistic regression analyzed the relationship between GDF-15

SUBMITTER: Ito H 

PROVIDER: S-EPMC11747562 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature