Reconstructing skeletal homeostasis through allogeneic hematopoietic stem cell transplantation in myelofibrosis.

ABSTRACT: Myeloproliferative neoplasm-associated myelofibrosis is a clonal stem cell process characterized by pronounced bone marrow fibrosis associated with extramedullary hematopoiesis and splenomegaly. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment leading to bone marrow fibrosis regression. Here we provide an in-depth skeletal characterization of myelofibrosis patients before and after allo-HSCT utilizing clinical high-resolution imaging, laboratory analyses, and bone biopsy studies. Despite unimpaired bone microarchitecture at peripheral skeletal sites, we observe a marked increase in bone mineral density at the lumbar spine and proximal femur, which is histologically related to severe bone marrow fibrosis and osteosclerosis, fully normaliz

SUBMITTER: Schaferskupper M 

PROVIDER: S-EPMC11747566 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature