Hepatotoxicity of statins: a real-world study based on the US Food and Drug Administration Adverse Event Reporting System database.

ABSTRACT:

Background

Statins, as an important class of lipid-lowering drugs, play a key role in the prevention and treatment of cardiovascular diseases. However, with their widespread use in clinical practice, some adverse events have gradually emerged. In particular, the hepatotoxicity associated with statins use has become one of the clinical concerns that require sufficient attention.

Methods

In this study, we conducted a comprehensive and detailed analysis of the hepatotoxicity of statins based on the data of the US Food and Drug Administration Adverse Event Reporting System database from the first quarter (Q1) of 2004 to the Q1 of 2024 and used Reporting Odds Ratios and Empirical Bayes Geometric Mean to mine the signal of adverse events.

Results

In this study, hepatic diso

SUBMITTER: Wang B 

PROVIDER: S-EPMC11747658 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature