Venous Endothelial Cell Transcriptomic Profiling Implicates METAP1 in Preeclampsia.

ABSTRACT:

Background

Preeclampsia is a hypertensive disorder of pregnancy characterized by systemic endothelial dysfunction. The pathophysiology of preeclampsia remains incompletely understood. This study used human venous endothelial cell (EC) transcriptional profiling to investigate potential novel mechanisms underlying EC dysfunction in preeclampsia.

Methods

Venous ECs were isolated from postpartum patients with severe preeclampsia and those with normotensive pregnancy using a J wire-based technique in the antecubital vein followed by CD144 (vascular endothelial cadherin) magnetic bead isolation. Venous EC transcriptomes were compared between preeclamptic and normotensive individuals. Differentially expressed genes were carried forward for genetic validation using expression quanti

SUBMITTER: Pabon MA 

PROVIDER: S-EPMC11747776 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature